国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Molecular and clinical characterization of PD-L1 expression at transcriptional level via 976 samples of brain glioma.
基本信息
- 负责人：Zheng Wang, Chuanbao Zhang
- 数据来源： OTHERS
- 论文编号：OTHERS20190380
- 发表时间：2016-11-01
2016-11-01
已发表文章
主要研究背景及目的
方法
In total, 976 glioma samples with transcriptome data, including 301 microarray data from Chinese Glioma Genome Atlas (CGGA project) and 675 RNAseq data from TCGA project, were enrolled into our study. Clinical and IDH mutation data were also available. R language was used as the main tool for statistical analysis and graphical work
结论
PD-L1 is upregulated in glioblastoma, and is synergistic with other check point members. Moreover, PD-L1 is significantly associated with T-cell activation and macrophage-related immune response and predicts much worse survival for patients, warranting clinical trials of PD1/PD-L1 checkpoint inhibitors for potential glioma treatment.