Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Molecular and clinical characterization of PD-L1 expression at transcriptional level via 976 samples of brain glioma.
First author：Zheng Wang, Chuanbao Zhang
Corresponding author：Wei Zhang, Tao Jiang
essential_information
- Person in charge：Zheng Wang, Chuanbao Zhang
- Data Sources： OTHERS
- Number of papers：OTHERS20190380
- Published time：2016-11-01
2016-11-01
Published articles
Journal：OncoImmunology
Publication type: Original Research
IF(IF): 8.11
PMID: 27999734 Link To Pubmed Full text Download
Background And Purpose
Method
In total, 976 glioma samples with transcriptome data, including 301 microarray data from Chinese Glioma Genome Atlas (CGGA project) and 675 RNAseq data from TCGA project, were enrolled into our study. Clinical and IDH mutation data were also available. R language was used as the main tool for statistical analysis and graphical work
Conclusion
PD-L1 is upregulated in glioblastoma, and is synergistic with other check point members. Moreover, PD-L1 is significantly associated with T-cell activation and macrophage-related immune response and predicts much worse survival for patients, warranting clinical trials of PD1/PD-L1 checkpoint inhibitors for potential glioma treatment.