Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes.
First author：Lingling Fang
Corresponding author：Weiqing Wan
essential_information
- Person in charge：Lingling Fang
- Data Sources： OTHERS
- Number of papers：OTHERS20190385
- Published time：2016-08-01
2016-08-01
Published articles
Journal：J Neurosurg
Publication type: Research Article
IF(IF): 5.115
PMID: 26722860 Link To Pubmed Full text Download
Background And Purpose
Method
The authors administered 5 typical executive function tests (the Stroop test, the Hayling Sentence Completion Test [HSCT], the verbal fluency [VF] test, the N-back test, and the Sustained Attention to Response Task [SART]) to 49 patients with MMD and 47 IQ-, age-, education-, and social status–matched healthy controls. The dysexecutive questionnaire (DEX) was also used to assess participants’ subjective feelings about their executive function. A total of 39 of the patients were evaluated by CT perfusion (CTP) before the assessments were performed, and the correlations among the performances of the patients on the above tests with the parameters of cerebral blood volume, cerebral blood flow (CBF), mean transit time (MTT), and time-to-peak (TTP) in the frontal lobes of these patients were also analyzed.
Conclusion
The patients with MMD exhibited impairments in semantic inhibition, executive processing, working memory, and sustained attention, but they were not aware of these deficits. Moreover, differences in dysexecutive function existed between the different subtypes of MMD. Hypoperfusion of the frontal lobe may be related to working memory and semantic inhibition impairments in patients with MMD