国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes.

第一作者：Lingling Fang

通讯作者：Weiqing Wan

moyamoya disease; dysexecutive function; presentat

基本信息

  • 负责人：Lingling Fang
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190385
  • 发表时间：2016-08-01

2016-08-01

已发表文章

发表杂志：J Neurosurg

发表类型: Research Article

影响因子(IF): 5.115

PMID: 26722860 Pubmed原文链接 全文下载

主要研究背景及目的

方法

The authors administered 5 typical executive function tests (the Stroop test, the Hayling Sentence Completion Test [HSCT], the verbal fluency [VF] test, the N-back test, and the Sustained Attention to Response Task [SART]) to  49 patients with MMD and 47 IQ-, age-, education-, and social status–matched healthy controls. The dysexecutive questionnaire (DEX) was also used to assess participants’ subjective feelings about their executive function. A total of 39 of  the patients were evaluated by CT perfusion (CTP) before the assessments were performed, and the correlations among  the performances of the patients on the above tests with the parameters of cerebral blood volume, cerebral blood flow  (CBF), mean transit time (MTT), and time-to-peak (TTP) in the frontal lobes of these patients were also analyzed.

结论

The patients with MMD exhibited impairments in semantic inhibition, executive processing, working memory, and sustained attention, but they were not aware of these deficits. Moreover, differences in dysexecutive  function existed between the different subtypes of MMD. Hypoperfusion of the frontal lobe may be related to working  memory and semantic inhibition impairments in patients with MMD

主要结果