国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Risk factors for worsened muscle strength after the surgical treatment of arteriovenous malformations of the eloquent motor area.

第一作者：Fuxin lin

通讯作者：shuo wang

functional magnetic resonance imaging; diffusion t

基本信息

  • 负责人：Fuxin lin
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190386
  • 发表时间：2016-08-01

2016-08-01

已发表文章

发表杂志：J Neurosurg

发表类型: Clinical Article

影响因子(IF): 5.115

PMID: 26636384 Pubmed原文链接 全文下载

主要研究背景及目的

方法

At their hospital the authors retrospectively studied 48 consecutive patients with AVMs involving motor cortex and/or the descending pathway. All patients had undergone preoperative functional MRI (fMRI) and diffusion tensor  imaging (DTI), followed by resection. Both functional and angioarchitectural factors were analyzed with respect to the  change in muscle strength. Functional factors included lesion-to-corticospinal tract distance (LCD) on DTI and lesion-toactivation area distance (LAD) and cortical reorganization on fMRI. Based on preoperative muscle strength, the changes  in muscle strength at 1 week and 6 months after surgery were defined as short-term and long-term surgical outcomes,  respectively. Statistical analysis was performed using the statistical package SPSS (version 20.0.0, IBM Corp.).

结论

An AVM with a nidus in contact with tracked eloquent fibers (LCD = 0) and having a large size is more likely to be associated with worsened muscle strength after surgery in patients with eloquent motor area AVMs. Surgical treatment in these patients should be carefully considered. In patients with an LCD > 5 mm, radical resection may be considered to eliminate the risk of hemorrhage

主要结果