Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Magnetic resonance angiography signal intensity as a marker of hemodynamic impairment in intracranial arterial stenosis
First author：Xinyi Leng
Corresponding author：Ka Sing Wong
essential_information
- Person in charge：Xinyi Leng
- Data Sources： CICAS
- Number of papers：CICAS20150087
- Published time：2013-11-26
2013-11-26
Published articles
Background And Purpose
BACKGROUND: Intracranial arterial stenosis (ICAS) is the predominant cause of ischemic stroke and transient ischemic attack in Asia. Change of signal intensities (SI) across an ICAS on magnetic resonance angiography (MRA) may reflect its hemodynamic severity. METHODS: In-patients with a symptomatic single ICAS detected on 3D time-of-flight MRA were recruited from 2 hospitals. Baseline and 1-year follow-up data were collected. Signal intensity ratio (SIR) [ = (mean post-stenotic SI -mean background SI)/(mean pre-stenotic SI - mean background SI)] was evaluated on baseline MRA to represent change of SIs across an ICAS. Acute infarct volume was measured on baseline diffusion-weighted images (DWI). Relationships between SIR and baseline characteristics as well as 1y outcomes were evaluated.