Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.
First author：Runfa Tian
Corresponding author：Baiyun Liu
essential_information
- Person in charge：Runfa Tian
- Data Sources： OTHERS
- Number of papers：OTHERS20190411
- Published time：2016-04-15
2016-04-15
Published articles
Journal：Brain Research
Publication type: Research Article
IF(IF): 3.252
PMID: 26826009 Link To Pubmed Full text Download
Background And Purpose
Method
A TBI model was induced using a controlled cortical impact injury. HRW or distilled water was injected intraperitoneally daily following surgery. We measured survival rate, brain edema, blood–brain barrier (BBB) breakdown and neurological dysfunction in all animals. Changes in inflammatory cytokines, inflammatory cells and Cho/Cr metabolites in brain tissues were also detected.
Conclusion
In conclusion, HRW could exert a neuroprotective effect against TBI and attenuate inflammation, which suggests HRW as an effective therapeutic strategy for TBI patients.