国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.

第一作者：Runfa Tian

通讯作者：Baiyun Liu

Anti-inflammatory Controlled cortical impact Hydro

基本信息

  • 负责人：Runfa Tian
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190411
  • 发表时间：2016-04-15

2016-04-15

已发表文章

发表杂志：Brain Research

发表类型: Research Article

影响因子(IF): 3.252

PMID: 26826009 Pubmed原文链接 全文下载

主要研究背景及目的

方法

A TBI model was induced using a controlled cortical impact injury. HRW or distilled water was injected intraperitoneally daily following surgery. We measured survival rate, brain edema, blood–brain barrier (BBB) breakdown and neurological dysfunction in all animals. Changes in inflammatory cytokines, inflammatory cells and Cho/Cr metabolites in brain tissues were also detected.

结论

In conclusion, HRW could exert a neuroprotective effect against TBI and attenuate inflammation, which suggests HRW as an effective therapeutic strategy for TBI patients.

主要结果