国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2016-10-01
已发表文章
主要研究背景及目的
方法
From January 2005 to December 2012, we retrospectively reviewed 52 pediatric meningiomas in terms of preoperative MRI features and their clinical data and followed them up from 22 to 128 months (mean 63 months) after the initial surgery. The relationships between these radiological findings and relapse-free survival (RFS) time were assessed initially with univariate Cox analysis and then corrected by multivariate Cox analysis. According to univariate analysis, irregular shape, narrow-based attachment, and skull base location were significantly correlated with shorter time to recurrences of meningiomas in pediatric patients. When corrected by multivariate analysis, irregular shape (P = 0.05; OR 3.442, 95 % CI 1.001–11.831) and narrow-based attachment (P = 0.004; OR 7.164, 95 % CI 1.894–27.09) were strong independent predictive factors for worse RFS of pediatric meningiomas.
结论
In pediatric population, narrow-based attachment and irregular shape were significantly correlated with recurrences of meningiomas.Our results could help clinicians to make optimaltherapeuticstrategies for pediatric patients with intracranial meningiomasbefore surgery.