Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Prediction of pediatric meningioma recurrence by preoperative MRI assessment.
First author：Hao Li
Corresponding author：Yong Cao, Jizong Zhao
essential_information
2016-10-01
Published articles
Journal：Neurosurgical Review
Publication type: Research Article
IF(IF): 3.042
PMID: 27037557 Link To Pubmed Full text Download
Background And Purpose
Method
From January 2005 to December 2012, we retrospectively reviewed 52 pediatric meningiomas in terms of preoperative MRI features and their clinical data and followed them up from 22 to 128 months (mean 63 months) after the initial surgery. The relationships between these radiological findings and relapse-free survival (RFS) time were assessed initially with univariate Cox analysis and then corrected by multivariate Cox analysis. According to univariate analysis, irregular shape, narrow-based attachment, and skull base location were significantly correlated with shorter time to recurrences of meningiomas in pediatric patients. When corrected by multivariate analysis, irregular shape (P = 0.05; OR 3.442, 95 % CI 1.001–11.831) and narrow-based attachment (P = 0.004; OR 7.164, 95 % CI 1.894–27.09) were strong independent predictive factors for worse RFS of pediatric meningiomas.
Conclusion
In pediatric population, narrow-based attachment and irregular shape were significantly correlated with recurrences of meningiomas.Our results could help clinicians to make optimaltherapeuticstrategies for pediatric patients with intracranial meningiomasbefore surgery.