Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The clinicopathological features of pituicytoma and the differential diagnosis of sellar glioma.
First author：Junmei Wang
Corresponding author：Guilin Li
essential_information
- Person in charge：Junmei Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190420
- Published time：2016-10-01
2016-10-01
Published articles
Journal：Neuropathology
Publication type: Research Article
IF(IF): 1.906
PMID: 26919073 Link To Pubmed Full text Download
Background And Purpose
Method
We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33–65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6- month period. Imaging findings revealed tumors were in the intrasellar region (four cases), suprasellar region (four cases) and intra-suprasellar regions (three cases).
Conclusion
Our results indicate that pituicytoma typically involves dense arrangements of spindle or slightly chubby cells. The morphology is occasionally atypical, with ependymoma-like or meningioma-like structures, and occasionally exhibits pilomyxoid degeneration. Abundant sinusoids are characteristic of hemorrhagic tumors. The dense spindle cell arrangement is a relatively specific morphology, and staining for GFAP, TTF-1, Olig2 andCD4 may help differentiate pituicytoma from sellar glioma.