国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Resting-state functional magnetic resonance imaging in patients with leukoaraiosis-associated subcortical vascular cognitive impairment: a cross-sectional study.
第一作者：Yu Chen
通讯作者：Yumei Zhang
2016-06-01
已发表文章
主要研究背景及目的
方法
All subjects (n = 58) were divided into two groups based on their clinical diagnosis: a LA-associated SVCI group (n = 31, 14 males) and a control group (n = 27, 14 males). Demographic information and resting-state functional MRI (rs-fMRI) data were obtained. These subjects were assessed using the Hamilton Anxiety Depression Scale, Clinical Dementia Rating, Mini Mental State Exam, and Montreal Cognitive Assessment. Experimental data and confounding factors were described with a General Liner Model. Independent components of fMRI data were analyzed with an fMRI toolbox.
结论
The present study provides neuroimaging evidence for the recognition of LA-associated SVCI. Moreover, the differences in the functional alterations of the resting-state DMN might be a distinguishing featurebetween SVCI and amnestic mild cognitive impairment patients.
主要结果
All subjects (n = 58) were divided into two groups based on their clinical diagnosis: a LA-associated SVCI group (n = 31, 14 males) and a control group (n = 27, 14 males). Demographic information and resting-state functional MRI (rs-fMRI) data were obtained. These subjects were assessed using the Hamilton Anxiety Depression Scale, Clinical Dementia Rating, Mini Mental State Exam, and Montreal Cognitive Assessment. Experimental data and confounding factors were described with a General Liner Model. Independent components of fMRI data were analyzed with an fMRI toolbox.