Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Potassium Aspartate Attenuates Brain Injury Induced by Controlled Cortical Impact in Rats Through Increasing Adenosine Triphosphate (ATP) Levels, Na+/K+-ATPase Activity and Reducing Brain Edema.
First author：Yi Gu, Jie Zhang
Corresponding author：Yazhuo Zhang
essential_information
- Person in charge：Yi Gu, Jie Zhang
- Data Sources： OTHERS
- Number of papers：OTHERS20190424
- Published time：2016-12-13
2016-12-13
Published articles
Journal：Med Sci Monit
Publication type: Animal Study
IF(IF): 1.98
PMID: 27959885 Link To Pubmed Full text Download
Background And Purpose
Method
TBI was induced by controlled cortical impact (CCI) in rats. Vehicle treatment (control) or PA treatment was administered intraperitoneally at 30 minutes after CCI. The modified neurological severity score (mNSS) and cortical lesion volume were examined. Brain edema and blood-brain barrier (BBB) integrity were measured, as well as brain ATP contents, lactic acid levels, and Na+/K+-ATPase activities.
Conclusion
Our results indicate PA has neuroprotective effects on TBI through increasing ATP levels, Na+/K+-ATPase activity, and reducing brain edema. It provides experimental evidence for the clinical application of PA