Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

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Apolipoprotein E epsilon4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population.

First author：Zhimei Li

Corresponding author：Tao Cui

APOE = apolipoprotein E FC = febrile convulsion

essential_information

  • Person in charge：Zhimei Li
  • Data Sources： OTHERS
  • Number of papers：OTHERS20190427
  • Published time：2016-01-01

2016-01-01

Published articles

Journal：Medicine (Baltimore)

Publication type: Observational Study

IF(IF): 1.87

PMID: 26945380 Link To Pubmed Full text Download

Background And Purpose

Method

The study consisted of total 308 NLMTLE patients and 302 controls in Han Chinese. The APOE polymorphisms were genotyped using polymerase chain reaction (PCR) DNA sequencing. We compared the frequency of APOEe4 allele and carrying status between NLMTLE patients and control subjects to test for the association of APOEe4 allele with NLMTLE clinical status

Conclusion

Our study provided an evidence that APOEe4 allele was a possible risk factor for NLMTLE, and further study with a larger sample is needed to warrant this finding.

Main results