国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Clinical analysis of leucine-rich glioma inactivated-1 protein antibody associated with limbic encephalitis onset with seizures.

第一作者：Zhimei Li

通讯作者：Qun Wang

cognitive deficits faciobrachial dystonic seizure

基本信息

  • 负责人：Zhimei Li
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190428
  • 发表时间：2016-07-01

2016-07-01

已发表文章

发表杂志：Medicine (Baltimore)

发表类型: Research Article

影响因子(IF): 1.87

PMID: 27428233 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We summarized the clinical characteristics of patients presenting with seizures and limbic encephalitis (LE) associated with leucinerich glioma inactivated-1 protein antibody (LGI1) in order help recognize and treat this condition at its onset. We analyzed clinical, video electroencephalogram (VEEG), magnetic resonance imaging (MRI), and laboratory data of 10 patients who presented with LGI1-LE and followed up their outcomes from 2 to 16 (9.4±4.2) months.

结论

LGI1-LE may initially manifest with various types of seizures, particularly FBDS and complex partial seizures (CPS) of mesial temporal origin, and slowly progressive cognitive involvement. Clinical follow-up, VEEG monitoring, and MRI scan are helpful in early diagnosis. Immunotherapy is effective for the treatment of both seizure and LE associated with LGI1 antibody. Although mostly nonparaneoplastic, tumor screening is recommended in some cases.

主要结果