国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Impact of tumor location and fourth ventricle infiltration in medulloblastoma.

第一作者：T Jiang

通讯作者：R Liu

Medulloblastoma . Prognosis . Treatment . Risk str

基本信息

  • 负责人：T Jiang
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190429
  • 发表时间：2016-06-01

2016-06-01

已发表文章

发表杂志：Acta Neurochirurgica

发表类型: Research Article

影响因子(IF): 2.216

PMID: 27106847 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We retrospectively followed all MB patients at the Beijing Tiantan Hospital between 2004 and 2007 to investigate treatment outcomes and prognostic factors in MB patients. The data of 119 patients were collected. Tumor removal was performed in all patients, and all patients received postsurgical radiotherapy or chemotherapy. The patients were subclassified into three subtypes according to tumor location and tumor infiltration into the fourth ventricular floor (V4 floor). The prognostic factors were analyzed using KaplanMeier and Cox regression analysis.

结论

According to the multivariate analysis, large cell and anaplastic (LC/A) subtype, patient age, and metastasis were found to be independent prognostic factors. Tumors with V4 floor infiltration exhibited a trend toward recurrence (P = 0.054). This investigation is the largest single-institution study of MB cases in China. The LC/A subtype, patient age, and metastasis were important prognostic factors. V4 floor infiltration was correlated with metastasis and younger age

主要结果