Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
essential_information
2016-06-01
Published articles
Journal：Acta Neurochirurgica
Publication type: Research Article
IF(IF): 2.216
PMID: 27106847 Link To Pubmed Full text Download
Background And Purpose
Method
We retrospectively followed all MB patients at the Beijing Tiantan Hospital between 2004 and 2007 to investigate treatment outcomes and prognostic factors in MB patients. The data of 119 patients were collected. Tumor removal was performed in all patients, and all patients received postsurgical radiotherapy or chemotherapy. The patients were subclassified into three subtypes according to tumor location and tumor infiltration into the fourth ventricular floor (V4 floor). The prognostic factors were analyzed using KaplanMeier and Cox regression analysis.
Conclusion
According to the multivariate analysis, large cell and anaplastic (LC/A) subtype, patient age, and metastasis were found to be independent prognostic factors. Tumors with V4 floor infiltration exhibited a trend toward recurrence (P = 0.054). This investigation is the largest single-institution study of MB cases in China. The LC/A subtype, patient age, and metastasis were important prognostic factors. V4 floor infiltration was correlated with metastasis and younger age