国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2017-02-01
已发表文章
主要研究背景及目的
方法
During the period from January 2008 to October 2015, we encountered 102 histologically established cases of CPPs, of which 21 were located in the CPA region. Clinical profiles, radiologic features, surgical procedures, intraoperative findings, and outcomes were extracted from the patient records and neuroimaging data.
结论
CPPs in the CPA region cannot be easily differentiated from other tumors preoperatively. Cysts and calcifications appear on neuroimaging. CPPs in the CPA region usually protrude inferiorly into the foramen magnum region. As much tumor should be removed as possible to avoid recurrence and malignant transition.
主要结果
A 45-year-old woman presented with a 6-year history of headache and typical symptoms of normal-pressure hydrocephalus, including gait disturbance, urinary incontinence, and cognitive dysfunction, in addition to the more common symptoms of CPP, such as lower cranial nerve dysfunctions and ataxia. The CPP arose from the right lateral recess of the fourth ventricle and extended to the cerebellopontine angle. Magnetic resonance imaging did not show any radiographic evidence of obstruction of aqueduct, foramen of Magendie, or foramen of Luschka on the contralateral side. We speculated that hydrocephalus was associated with cerebrospinal fluid overproduction by the CPP originating from the choroid plexus of the lateral recess and extending laterally into the cerebellomedullary fissure (CMF). Surgical excision was performed with a trans-CMF approach. The symptoms of normal-pressure hydrocephalus disappeared. In addition to improved clinical symptoms, radiographic findings showed mitigation of ventricular dilatation.