Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Long Noncoding RNAs and Their Regulatory Network: Potential Therapeutic Targets for Adult Moyamoya Disease.
First author：Faliang Gao
Corresponding author：Jizong Zhao
essential_information
- Person in charge：Faliang Gao
- Data Sources： OTHERS
- Number of papers：OTHERS20190443
- Published time：2016-09-01
2016-09-01
Published articles
Journal：World Neurosurg
Publication type: Research Article
IF(IF): 2.104
PMID: 27268316 Link To Pubmed Full text Download
Background And Purpose
Method
A healthy control group (n [ 10) and an MMD group (n [ 15) were evaluated. RNA was extracted from peripheral blood samples and hybridized to microarray to get lncRNA expression profiles. Then predicted lncRNA target genes were identified, and bioinformatics analysis was performed to investigate their molecular functions
Conclusion
Long noncoding RNA expression profiles were quite different between MMD and control groups. Multiple signaling pathways that were closely associated with immune response, vasculogenesis, and smooth muscle contraction were indicated to participate in lncRNAs regulatory mechanism; of these, MAPK signaling pathway, which has been well studied for the treatment of many other cardiovascular diseases, was the core of this regulatory network. Our findings could help further understand the pathophysiology of MMD and provide new potential therapeutic targets.
Main results
A healthy control group (n = 10) and an MMD group (n = 15) were evaluated. RNA was extracted from peripheral blood samples and hybridized to microarray to get lncRNA expression profiles. Then predicted lncRNA target genes were identified, and bioinformatics analysis was performed to investigate their molecular functions.