Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Bone invasiveness is associated with prognosis in clivus chordomas.
First author：Ke Wang
Corresponding author：Junting Zhang
essential_information
2016-03-30
Published articles
Journal：Journal of Clinical Neuroscience
Publication type: Research Article
IF(IF): 1.961
PMID: 26810468 Link To Pubmed Full text Download
Background And Purpose
Method
Clinical data, MRI, CT scans and follow-up data were examined, and the bone invasiveness of the chordoma was classified into two growth patterns (endophytic and exophytic) which were analyzed with regard to prognosis.
Conclusion
Chordomas with an exophytic growth pattern were more likely to recur than those with an endophytic growth pattern, and the surgical approach can be tailored according to each growth pattern.
Main results
The overall survival rate was 78.9% with radical surgery and adjuvant radiation, with a mean follow-up of 44.5months. There were 12 patients in the endophytic group and seven in the exophytic group, and the exophytic group exhibited a higher recurrence rate than the endophytic group (p=0.006).