Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study
First author：Qian,Yining,Pu, Yuehua
Corresponding author：Wang, Yongjun
essential_information
- Person in charge：Qian,Yining,Pu, Yuehua
- Data Sources： CICAS
- Number of papers：CICAS20150095
- Published time：2013-05-17
2013-05-17
Published articles
Background And Purpose
BACKGROUND: Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke. METHODS: From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA). Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888) and non-intracranial stenosis (NICAS group, n = 1096). Serum lipid profiles were analyzed and compared between the ICAS and NICAS group.