Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Seizure as the unique clinical manifestation of cerebral metastases in a 27-year-old man with non-small cell lung cancer

First author:Lv Rui-Juan

Corresponding author:Shao Xiao-Qiu

essential_information

  • Person in charge:Lv Rui-Juan
  • Data Sources: OTHERS
  • Number of papers:OTHERS20190700
  • Published time:2018-04-01

2018-04-01

Published articles

Journal:Neurological Sciences

Publication type: Article

IF(IF): 3.307

PMID: 29198042 Link To Pubmed Full text Download

Background And Purpose

Method

A 27-year-old man presented to the emergency department during Chinese spring festival with a history of seizures that had been occurring for the previous 5 days. The seizures were described by the paramedics as well as by bystanders as a Jacksonian seizure affecting the right limb, followed by a generalized tonic-clonic seizure lasting approximately 3 min. The patient had Todd’s paralysis of the right limb following each seizure. He did not exhibit any confusion between episodes and suffered approximately four seizures per day. The patient had previously been healthy. The family history was negative for seizures, endocrine disorders, or neoplasms. On physical examination, his vital signs were within normal limits, and he did not exhibit any focal neurological signs. Results of laboratory diagnostic tests performed on admission were within normal limits. Electroencephalogram (EEG) was performed at another hospital and demonstrated a few amount of spikes in the left temporal and frontal regions. Brain magnetic resonance imaging (MRI) without enhancement was performed at the same hospital as the EEG and did not reveal any abnormalities. A thoracic Xray showed normal results. Following these initial tests, the patient was diagnosed as epilepsy without known cause.

Conclusion

inanyadultpatientwithanew-onsetseizure disorder, the possibility of a cerebral metastasis from lung cancershouldbeconsidered.Thelungsshouldbethefirstsite of evaluation in cases of a cerebral metastasis with an unknown primary tumor. Although the positive rate of the CSF cytology for direct visualization of tumor cells is not very high, it is a highly important diagnostic tool for LC.

Main results