国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Seizure as the unique clinical manifestation of cerebral metastases in a 27-year-old man with non-small cell lung cancer

第一作者:Lv Rui-Juan

通讯作者:Shao Xiao-Qiu

基本信息

  • 负责人:Lv Rui-Juan
  • 数据来源: OTHERS
  • 论文编号:OTHERS20190700
  • 发表时间:2018-04-01

2018-04-01

已发表文章

发表杂志:Neurological Sciences

发表类型: Article

影响因子(IF): 3.307

PMID: 29198042 Pubmed原文链接 全文下载

主要研究背景及目的

方法

A 27-year-old man presented to the emergency department during Chinese spring festival with a history of seizures that had been occurring for the previous 5 days. The seizures were described by the paramedics as well as by bystanders as a Jacksonian seizure affecting the right limb, followed by a generalized tonic-clonic seizure lasting approximately 3 min. The patient had Todd’s paralysis of the right limb following each seizure. He did not exhibit any confusion between episodes and suffered approximately four seizures per day. The patient had previously been healthy. The family history was negative for seizures, endocrine disorders, or neoplasms. On physical examination, his vital signs were within normal limits, and he did not exhibit any focal neurological signs. Results of laboratory diagnostic tests performed on admission were within normal limits. Electroencephalogram (EEG) was performed at another hospital and demonstrated a few amount of spikes in the left temporal and frontal regions. Brain magnetic resonance imaging (MRI) without enhancement was performed at the same hospital as the EEG and did not reveal any abnormalities. A thoracic Xray showed normal results. Following these initial tests, the patient was diagnosed as epilepsy without known cause.

结论

inanyadultpatientwithanew-onsetseizure disorder, the possibility of a cerebral metastasis from lung cancershouldbeconsidered.Thelungsshouldbethefirstsite of evaluation in cases of a cerebral metastasis with an unknown primary tumor. Although the positive rate of the CSF cytology for direct visualization of tumor cells is not very high, it is a highly important diagnostic tool for LC.

主要结果