Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Prognostic factors and the management of anaplastic meningioma
First author：Zhang Gui-Jun, Gui-Jun
Corresponding author：Zhang Jun-Ting, Jun-Ting
essential_information
- Person in charge：Zhang Gui-Jun, Gui-Jun
- Data Sources： OTHERS
- Number of papers：OTHERS20190754
- Published time：2018-07-01
2018-07-01
Published articles
Journal：Clinical Neurology and Neurosurgery
Publication type: Article
IF(IF): 1.876
PMID: 29715576 Link To Pubmed Full text Download
Background And Purpose
Method
All patients (n = 56) underwent surgeries in our hospital between December 2008 and January 2016. Postoperative pathology reports confirmed the diagnosis of AM. Prognostic factors and the management were analysed in this study. AM was then divided into two groups. One group was primary AM, the other group was secondary AM.
Conclusion
Achieving GTR is a favourable treatment strategy for patients with AM in our study and patients receiving PRT after resection is essential.
Main results
Of all the 56 AM patients, 31 were male and 25 were female (male to female ratio of 1.24:1). The 1-, 3-, and 5-year progression-free survival (PFS) rates were 78.6%, 41.1% and 29.7%, respectively, and the corresponding overall survival (OS) rates were 82.1%, 50.1% and 45.0%, respectively. Homogeneous contrast might be a potential better prognostic factor for PFS (HR = 1.824, P = 0.083). Treatment with postoperative radiotherapy (PRT) was significantly associated with longer PFS (HR = 0.390, P = 0.007) and OS (HR = 0.376, P = 0.008) according to univariate analysis. Gross-total resection (GTR) was a favourable factor for PFS (HR = 2.059, P = 0.035) and OS (HR = 2.802, P = 0.004).