国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Prognostic factors and the management of anaplastic meningioma

第一作者：Zhang Gui-Jun, Gui-Jun

通讯作者：Zhang Jun-Ting, Jun-Ting

Anaplastic meningioma Prognosis Treatment Tumor pr

基本信息

2018-07-01

已发表文章

发表杂志：Clinical Neurology and Neurosurgery

发表类型: Article

影响因子(IF): 1.876

PMID: 29715576 Pubmed原文链接 全文下载

主要研究背景及目的

方法

All patients (n = 56) underwent surgeries in our hospital between December 2008 and January 2016. Postoperative pathology reports confirmed the diagnosis of AM. Prognostic factors and the management were analysed in this study. AM was then divided into two groups. One group was primary AM, the other group was secondary AM.

结论

Achieving GTR is a favourable treatment strategy for patients with AM in our study and patients receiving PRT after resection is essential.

主要结果

Of all the 56 AM patients, 31 were male and 25 were female (male to female ratio of 1.24:1). The 1-, 3-, and 5-year progression-free survival (PFS) rates were 78.6%, 41.1% and 29.7%, respectively, and the corresponding overall survival (OS) rates were 82.1%, 50.1% and 45.0%, respectively. Homogeneous contrast might be a potential better prognostic factor for PFS (HR = 1.824, P = 0.083). Treatment with postoperative radiotherapy (PRT) was significantly associated with longer PFS (HR = 0.390, P = 0.007) and OS (HR = 0.376, P = 0.008) according to univariate analysis. Gross-total resection (GTR) was a favourable factor for PFS (HR = 2.059, P = 0.035) and OS (HR = 2.802, P = 0.004).