Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Proposed Treatment for Intracranial Transitional Meningioma: A Single-Center Series of 298 Cases
First author：Ma Xiu-Jian,Zhang Gui-Jun,Wang Wei
Corresponding author：Zhang Jun-Ting
essential_information
- Person in charge：Ma Xiu-Jian,Zhang Gui-Jun,Wang Wei
- Data Sources： OTHERS
- Number of papers：OTHERS20190857
- Published time：2019-03-19
2019-03-19
Published articles
Journal：World Neurosurgery
Publication type: Original Article
IF(IF): 2.104
PMID: 30902770 Link To Pubmed Full text Download
Background And Purpose
Method
We included 298 patients who had undergone surgery from September 2011 to August 2013. The clinical characteristics, surgical record, and follow-up data for these patients were retrieved.
Conclusion
The results from the present study have shown that GTR should be achieved during the first surgery for TM. Gamma knife radiosurgery might be an effective therapy for patients with tumor recurrence.
Main results
The 298 enrolled patients included 213 women (71.5%). The mean and median age of the 298 patients was 50.7 ± 0.6 years and 52.0 years (range, 6.0-74.0), respectively. Radiologically, 144 tumors (48.3%) were located in the skull base. Gross total resection (GTR) was achieved in 266 patients (89.3%); 7 patients (2.6%) received adjuvant radiotherapy. After a median follow-up of 61.8 months, 23 patients (8.6%) had developed recurrence and 2 patients (0.8%) had died. The results from univariate analysis indicated that GTR was associated with better progression-free survival (hazard ratio, 0.165; 95% confidence interval, 0.071-0.382; P < 0.001).) Skull base tumors tended to predict for poor progression-free survival (hazard ratio, 2.169; 95% confidence interval, 0.919-5.118; P = 0.077). For the first tumor recurrence, 11 patients (47.8%) underwent gamma knife radiosurgery, and only 2 patients developed a second recurrence.