国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Proposed Treatment for Intracranial Transitional Meningioma: A Single-Center Series of 298 Cases

第一作者：Ma Xiu-Jian,Zhang Gui-Jun,Wang Wei

通讯作者：Zhang Jun-Ting

Gross total resection Proposed treatment Transitio

基本信息

2019-03-19

已发表文章

发表杂志：World Neurosurgery

发表类型: Original Article

影响因子(IF): 2.104

PMID: 30902770 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We included 298 patients who had undergone surgery from September 2011 to August 2013. The clinical characteristics, surgical record, and follow-up data for these patients were retrieved.

结论

The results from the present study have shown that GTR should be achieved during the first surgery for TM. Gamma knife radiosurgery might be an effective therapy for patients with tumor recurrence.

主要结果

The 298 enrolled patients included 213 women (71.5%). The mean and median age of the 298 patients was 50.7 ± 0.6 years and 52.0 years (range, 6.0-74.0), respectively. Radiologically, 144 tumors (48.3%) were located in the skull base. Gross total resection (GTR) was achieved in 266 patients (89.3%); 7 patients (2.6%) received adjuvant radiotherapy. After a median follow-up of 61.8 months, 23 patients (8.6%) had developed recurrence and 2 patients (0.8%) had died. The results from univariate analysis indicated that GTR was associated with better progression-free survival (hazard ratio, 0.165; 95% confidence interval, 0.071-0.382; P < 0.001).) Skull base tumors tended to predict for poor progression-free survival (hazard ratio, 2.169; 95% confidence interval, 0.919-5.118; P = 0.077). For the first tumor recurrence, 11 patients (47.8%) underwent gamma knife radiosurgery, and only 2 patients developed a second recurrence.