Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Gastrointestinal bleeding during acute ischemic stroke hospitalization increases the risk of stroke recurrence
First author：Wanliang Du
Corresponding author：Yongjun Wang,Penglian Wang
essential_information
- Person in charge：Wanliang Du
- Data Sources： CNSR-I
- Number of papers：CNSR-I20190968
- Published time：2020-06-01
2020-06-01
Published articles
Journal：Stroke and Vascular Neurology
Publication type: Original Contributions
IF(IF): 4.081
PMID: 32606083 Link To Pubmed Full text Download
Background And Purpose
Gastrointestinal (GI) bleeding in stroke patients is strongly associated with a higher risk of death and loss of independence. However, it is unknown whether GI bleeding increases risk for recurrence of stroke. In this study, we assess the potential relationship between GI bleeding and stroke recurrence in patients within 12 months of an acute ischemic stroke (AIS), using the China National Stroke Registry (CNSR).
Method
This study included 22 216 patients who had an ischaemic stroke included in the CNSR from 2007 to 2008. We analysed baseline patient characteristics, GI bleeding and outcomes of patients who had an AIS, specifically stroke recurrence at 3, 6 and 12 months. We used multivariable logistic regression to evaluate a possible association between GI bleeding and stroke recurrence.
Conclusion
GI bleeding was associated with the increased risk of stroke recurrence after an AIS.
Main results
Of the 12 415 patients included in our study, 12.3%, 15.5% and 17.7% had a stroke recurrence at 3, 6 and 12 months, respectively. GI bleeding was an independent stroke recurrence risk factor in patients after ischaemic stroke at 3 months (adjusted OR 1.481, 95% CI 1.118 to 1.962), 6 months (adjusted OR 1.448, 95% CI 1.106 to 1.896) and 12 months (adjusted OR 1.350; 95% CI 1.034 to 1.763).