国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Gastrointestinal bleeding during acute ischemic stroke hospitalization increases the risk of stroke recurrence
第一作者：Wanliang Du
基本信息
- 负责人：Wanliang Du
- 数据来源： CNSR-I
- 论文编号：CNSR-I20190968
- 发表时间：2020-06-01
2020-06-01
已发表文章
发表杂志：Stroke and Vascular Neurology
发表类型: Original Contributions
影响因子(IF): 4.081
PMID: 32606083 Pubmed原文链接 全文下载
主要研究背景及目的
Gastrointestinal (GI) bleeding in stroke patients is strongly associated with a higher risk of death and loss of independence. However, it is unknown whether GI bleeding increases risk for recurrence of stroke. In this study, we assess the potential relationship between GI bleeding and stroke recurrence in patients within 12 months of an acute ischemic stroke (AIS), using the China National Stroke Registry (CNSR).
方法
This study included 22 216 patients who had an ischaemic stroke included in the CNSR from 2007 to 2008. We analysed baseline patient characteristics, GI bleeding and outcomes of patients who had an AIS, specifically stroke recurrence at 3, 6 and 12 months. We used multivariable logistic regression to evaluate a possible association between GI bleeding and stroke recurrence.
结论
GI bleeding was associated with the increased risk of stroke recurrence after an AIS.
主要结果
Of the 12 415 patients included in our study, 12.3%, 15.5% and 17.7% had a stroke recurrence at 3, 6 and 12 months, respectively. GI bleeding was an independent stroke recurrence risk factor in patients after ischaemic stroke at 3 months (adjusted OR 1.481, 95% CI 1.118 to 1.962), 6 months (adjusted OR 1.448, 95% CI 1.106 to 1.896) and 12 months (adjusted OR 1.350; 95% CI 1.034 to 1.763).