Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Sex differences in vascular risk factors, in- hospital management, and outcomes of patients with acute ischemic
First author：Hong-Qiu Gu
Corresponding author：Yong-Jun Wang,Zi-Xiao Li
essential_information
- Person in charge：Hong-Qiu Gu
- Data Sources： CSCA
- Number of papers：CSCA20190974
- Published time：2021-09-26
2021-09-26
Published articles
Journal：Eur J Neurol.
Publication type: Original Contributions
IF(IF): 6.089
PMID: 34564908 Link To Pubmed Full text Download
Background And Purpose
Sex-specific disparities in in-hospital stroke care and outcomes remain unclear. We sought to determine sex-specific differences in ischemic stroke performance metrics and in-hospital outcomes using the best available contemporary data from China Stroke Center Alliance.
Method
The study population was categorized according to sex. Patient characteristics , key performance indicators, and in-hospital outcomes in each group were described using frequencies and percentages for categorical variables and median (with 25th and 75th percentiles) for continuous variables. Differences in the 2 groups were compared by the use of ASDs. Multiple Logistic regression models with adjustment for patients and hospital-level covariates were used to compare the outcome between men and women.
Conclusion
Compared to male patients, female patients had more vascular risk factors and received similar in-hospital care. They had strokes that were more severe at presentation and more disabilities at discharge, both of which may be explained by worse vascular risk profiles.
Main results
Of 838,229 patients analyzed, 524351 (62.6%) were men and 313,878 (37.4%) were women. Compared with men, women were older (68.6 vs. 64.7 years), had higher prevalence of hypertension (67.7% vs 62.4%), diabetes (24.7% vs 19.5%), and atrial fibrillation (7.1% vs 4.3%), but lower prevalence of smoking (4.5% vs 56.6%) and drinking (2.6% vs 35.8%) (ASDs >10%). No sex differences were seen in guideline-directed management measures, indicated by risk-adjusted individual measures and the all-or-null summary measure (34.5% vs 34.9%, ASD=1.0%). Compared to men, women tended to have strokes that were more severe at presentation (6.5% vs 4.5%, ASD=8.8%) and more disabilities at discharge (34.9% vs 30.5%, ASD = 9.4%). However, all sex-related differences in outcomes were attenuated to null after risk adjustments (ASDs<2%)