国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Sex differences in vascular risk factors, in- hospital management, and outcomes of patients with acute ischemic
第一作者：Hong-Qiu Gu
基本信息
- 负责人：Hong-Qiu Gu
- 数据来源： CSCA
- 论文编号：CSCA20190974
- 发表时间：2021-09-26
2021-09-26
已发表文章
主要研究背景及目的
Sex-specific disparities in in-hospital stroke care and outcomes remain unclear. We sought to determine sex-specific differences in ischemic stroke performance metrics and in-hospital outcomes using the best available contemporary data from China Stroke Center Alliance.
方法
The study population was categorized according to sex. Patient characteristics , key performance indicators, and in-hospital outcomes in each group were described using frequencies and percentages for categorical variables and median (with 25th and 75th percentiles) for continuous variables. Differences in the 2 groups were compared by the use of ASDs. Multiple Logistic regression models with adjustment for patients and hospital-level covariates were used to compare the outcome between men and women.
结论
Compared to male patients, female patients had more vascular risk factors and received similar in-hospital care. They had strokes that were more severe at presentation and more disabilities at discharge, both of which may be explained by worse vascular risk profiles.
主要结果
Of 838,229 patients analyzed, 524351 (62.6%) were men and 313,878 (37.4%) were women. Compared with men, women were older (68.6 vs. 64.7 years), had higher prevalence of hypertension (67.7% vs 62.4%), diabetes (24.7% vs 19.5%), and atrial fibrillation (7.1% vs 4.3%), but lower prevalence of smoking (4.5% vs 56.6%) and drinking (2.6% vs 35.8%) (ASDs >10%). No sex differences were seen in guideline-directed management measures, indicated by risk-adjusted individual measures and the all-or-null summary measure (34.5% vs 34.9%, ASD=1.0%). Compared to men, women tended to have strokes that were more severe at presentation (6.5% vs 4.5%, ASD=8.8%) and more disabilities at discharge (34.9% vs 30.5%, ASD = 9.4%). However, all sex-related differences in outcomes were attenuated to null after risk adjustments (ASDs<2%)