Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of poor prognosis with total homocysteine levels in patients with intracerebral hemorrhage
First author：Dandan Wang
Corresponding author：Xingquan Zhao
essential_information
- Person in charge：Dandan Wang
- Data Sources：
- Number of papers：脑出血登记20200022
- Published time：2020-09-09
2020-09-09
Published articles
Journal：frontiers in neurology
Publication type: Original Article
IF(IF): 4.003
PMID: 0 Full text Download
Background And Purpose
Homocysteine is an intermediate sulfhydryl-containing amino acid. According to previous studies, high level of Hcy could induce a neuro-inflammatory process due to its abilities to react with cytokines in the brain, leading to increased permeability of blood-brain barrier and impaired integrity of cerebral vessels. There is convincing evidence that elevated plasma Hcy level is associated with higher poor prognosis from ischemic stroke, it is still unclear whether the Hcy level is associated with the prognosis of ICH. So we aimed to find the relationship between Hcy levels and poor prognosis of ICH in a Chinese population.
Method
It is a cohort study. We aimed to use Person test and logistic regression to find the relationship between Hcy levels and poor prognosis of ICH.
Conclusion
High Hcy level was independently associated with poorer 3-month prognosis and a lower survival rate within one year in patients with ICH.