国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of poor prognosis with total homocysteine levels in patients with intracerebral hemorrhage

第一作者：Dandan Wang

通讯作者：Xingquan Zhao

intracerebral hemorrhage homocysteine prognosis

基本信息

  • 负责人：Dandan Wang
  • 数据来源：
  • 论文编号：脑出血登记20200022
  • 发表时间：2020-09-09

2020-09-09

已发表文章

发表杂志：frontiers in neurology

发表类型: Original Article

影响因子(IF): 4.003

PMID: 0 全文下载

主要研究背景及目的

Homocysteine is an intermediate sulfhydryl-containing amino acid. According to previous studies, high level of Hcy could induce a neuro-inflammatory process due to its abilities to react with cytokines in the brain, leading to increased permeability of blood-brain barrier and impaired integrity of cerebral vessels. There is convincing evidence that elevated plasma Hcy level is associated with higher poor prognosis from ischemic stroke, it is still unclear whether the Hcy level is associated with the prognosis of ICH. So we aimed to find the relationship between Hcy levels and poor prognosis of ICH in a Chinese population.

方法

It is a cohort study. We aimed to use Person test and logistic regression to find the relationship between Hcy levels and poor prognosis of ICH.

结论

High Hcy level was independently associated with poorer 3-month prognosis and a lower survival rate within one year in patients with ICH.

主要结果