Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：stroke

Publication type: Original Contributions

IF(IF): 7.914

PMID: 34281380 Link To Pubmed Full text Download

It’s still unclear whether the residual cholesterol and inflammatory risk in the acute phase are associated with prognosis of ischemic stroke and TIA. We aimed to investigate the relative contribution of LDL-c and hsCRP to the risk of recurrent stroke and poor functional outcome.

In this prospective multicenter cohort study, a prespecified biomarker substudy of the Third China National Stroke Registry (CNSR-III), 10,500 consecutive acute ischemic stroke and transient ischemic attack (TIA) patients with baseline levels of LDL_c and hsCRP were enrolled. Patients were divided into four groups based on the LDL-c and hsCRP levels. Proportions for each group are presented. The associations of residual cholesterol/inflammatory risk with recurrent stroke and functional outcome were analyzed by using Cox proportional-hazards and logistic regression models. In the sensitive analyses, we further used alternative cut-off values for LDL-c and hsCRP. Association of residual inflammatory risk with outcomes within one year among the patients with LDL_c levels<1.8mmol/L at baseline and 3-month were also analyzed.