国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Residual Inflammatory Risk Predicts Poor Prognosis in Acute Ischemic Stroke or Transient Ischemic Attack Patients

第一作者：黎洁洁

通讯作者：王拥军

stroke

基本信息

  • 负责人：黎洁洁
  • 数据来源： CNSR-Ⅲ
  • 论文编号：CNSR-Ⅲ20200120
  • 发表时间：2021-07-20

2021-07-20

已发表文章

发表杂志：stroke

发表类型: Original Contributions

影响因子(IF): 7.914

PMID: 34281380 Pubmed原文链接 全文下载

主要研究背景及目的

It’s still unclear whether the residual cholesterol and inflammatory risk in the acute phase are associated with prognosis of ischemic stroke and TIA. We aimed to investigate the relative contribution of LDL-c and hsCRP to the risk of recurrent stroke and poor functional outcome.

方法

In this prospective multicenter cohort study, a prespecified biomarker substudy of the Third China National Stroke Registry (CNSR-III), 10,500 consecutive acute ischemic stroke and transient ischemic attack (TIA) patients with baseline levels of LDL_c and hsCRP were enrolled. Patients were divided into four groups based on the LDL-c and hsCRP levels. Proportions for each group are presented. The associations of residual cholesterol/inflammatory risk with recurrent stroke and functional outcome were analyzed by using Cox proportional-hazards and logistic regression models. In the sensitive analyses, we further used alternative cut-off values for LDL-c and hsCRP. Association of residual inflammatory risk with outcomes within one year among the patients with LDL_c levels<1.8mmol/L at baseline and 3-month were also analyzed.

结论

In the patients with acute ischemic stroke or TIA, residual inflammatory risk only could be predictive for recurrent stroke, especially for those with large-artery atherosclerosis, and poor functional outcome.

主要结果