Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Interplay between Inflammation, Overweight and Cognitive Impairment in a Community-based Population of Chinese Adults
First author：Wang Jing
Corresponding author：Zhao Xingquan
essential_information
2020-12-08
Published articles
Journal：Frontiers in Neurology
Publication type: Original Contributions
IF(IF): 4.003
PMID: 33363509 Link To Pubmed Full text Download
Background And Purpose
To determine the association of overweight, high-sensitivity C-reactive protein (hs-CRP) and risk of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.
Method
All participants of the APAC study were devided into 2 groups according to BMI (BMI <25 Kg/m2, BMI ≥25kg/m2). Cox proportional hazards models were used to assess the interaction of hsCRP levels with the effects of MMSE in participants with overweight or without.
Conclusion
In normal weight participants, elevated hs-CRP levels increased the risk of cognitive impairment, but not in overweight participants.
Main results
Of the 3,875 participants, 1,788 (46.1%) were overweight, while 2,087 (53.9%) were not. Before and after adjusting for all possible confounders, elevated hs-CRP levels increased the risk of cognitive impairment in normal weight participants (crude OR 2.08, 95%CI 1.28-3.37, p=0.003; adjusted OR 1.97, 95%CI 1.06-3.65, p=0.03), but not in overweight participants (crude OR 0.88, 95%CI 0.53-1.45, p=0.61; adjusted OR 0.57, 95%CI 0.29-1.11, p=0.10). There was not any statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-items.