国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Interplay between Inflammation, Overweight and Cognitive Impairment in a Community-based Population of Chinese Adults
第一作者：Wang Jing
通讯作者：Zhao Xingquan
2020-12-08
已发表文章
发表杂志：Frontiers in Neurology
发表类型: Original Contributions
影响因子(IF): 4.003
PMID: 33363509 Pubmed原文链接 全文下载
主要研究背景及目的
To determine the association of overweight, high-sensitivity C-reactive protein (hs-CRP) and risk of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.
方法
All participants of the APAC study were devided into 2 groups according to BMI (BMI <25 Kg/m2, BMI ≥25kg/m2). Cox proportional hazards models were used to assess the interaction of hsCRP levels with the effects of MMSE in participants with overweight or without.
结论
In normal weight participants, elevated hs-CRP levels increased the risk of cognitive impairment, but not in overweight participants.
主要结果
Of the 3,875 participants, 1,788 (46.1%) were overweight, while 2,087 (53.9%) were not. Before and after adjusting for all possible confounders, elevated hs-CRP levels increased the risk of cognitive impairment in normal weight participants (crude OR 2.08, 95%CI 1.28-3.37, p=0.003; adjusted OR 1.97, 95%CI 1.06-3.65, p=0.03), but not in overweight participants (crude OR 0.88, 95%CI 0.53-1.45, p=0.61; adjusted OR 0.57, 95%CI 0.29-1.11, p=0.10). There was not any statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-items.