Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Journal of Atherosclerosis and Thrombosis

Publication type: Original Contributions

IF(IF): 4.394

PMID: 35934783 Link To Pubmed Full text Download

CRP reflected instability of atherosclerotic plaque and was an important risk factor of stroke recurrence in ischemic stroke and TIA. Baseline imaging features such as arterial stenosis and patterns of infarction were also indicated to be related to stroke recurrence. Studies had showed that combination of these markers could improve the effect of risk stratification in minor stroke or TIA. However, it’s remain unclear whether it was consistent in all patients with ischemic stroke and TIA. What’s more, we aimed to evaluated their relationships in different etiological subtypes.

Hs-CRP levels : 0–3 mg/L, >3 mg/L; patterns of acute infarction: multiple infarctions , single infarction, no acute infarction; intracranial arterial stenosis: symptomatic intracranial artery stenosis, non-symptomatic intracranial artery stenosis, non-intracranial artery stenosis; We assessed the associations between different combinations of there markers and stroke outcomes using multivariable Cox regression models. Similar analysis was used based on different etiological subtypes. Adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) were calculated.