国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Elevated hs-CRP and Symptomatic Intracranial/Extracranial Artery Stenosis Predict Stroke Recurrence after Acute Ischemic Stroke or TIA
第一作者：Shiyu Li
通讯作者：Yongjun Wang
2022-08-06
已发表文章
发表杂志：Journal of Atherosclerosis and Thrombosis
发表类型: Original Contributions
影响因子(IF): 4.394
PMID: 35934783 Pubmed原文链接 全文下载
主要研究背景及目的
CRP reflected instability of atherosclerotic plaque and was an important risk factor of stroke recurrence in ischemic stroke and TIA. Baseline imaging features such as arterial stenosis and patterns of infarction were also indicated to be related to stroke recurrence. Studies had showed that combination of these markers could improve the effect of risk stratification in minor stroke or TIA. However, it’s remain unclear whether it was consistent in all patients with ischemic stroke and TIA. What’s more, we aimed to evaluated their relationships in different etiological subtypes.
方法
Hs-CRP levels : 0–3 mg/L, >3 mg/L; patterns of acute infarction: multiple infarctions , single infarction, no acute infarction; intracranial arterial stenosis: symptomatic intracranial artery stenosis, non-symptomatic intracranial artery stenosis, non-intracranial artery stenosis; We assessed the associations between different combinations of there markers and stroke outcomes using multivariable Cox regression models. Similar analysis was used based on different etiological subtypes. Adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) were calculated.
结论
Symptomatic intracranial or extracranial artery stenosis was associated with increased risk of recurrent ischemic stroke, stroke, and CVE at 1 year in patients with AIS or TIA, especially in patients with elevated hs-CRP levels. Asymptomatic intracranial or extracranial artery stenosis did not increase the risk of ischemic events compared with no artery stenosis regardless of hs-CRP levels.