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Change in triglyceride-glucose index predicts the risk of cardiovascular disease in the general population: a prospective cohort study

First author：Anxin Wang,Xue Tian

Corresponding author：Shouling Wu,Yongjun Wang

Triglyceride-glucose index; Longitudinal changes; Cardiovascular disease; Stroke; Myocardial infarction; Predictive value

essential_information

2021-05-26

Published articles

Journal：Cardiovascular Diabetology

Publication type: Original Contributions

IF(IF): 9.951

PMID: https://pubmed.ncbi.nlm.nih.gov/34039351/ Link To Pubmed Full text Download

Background And Purpose

Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and subsequent cardiovascular disease (CVD). However, the effect of longitudinal changes in TyG index on the risk of CVD remains uncertain. This study aimed to investigate the association between change in TyG index and the risk of CVD in the general population.

Method

The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2], and change in TyG index was defined as the difference between the TyG index in 2010 and that in 2006. Multivariable-adjusted Cox proportional hazard models and restricted cubic spline analysis were used to examine the association between change in TyG index and the risk of CVD.

Conclusion

Substantial changes in TyG index independently predict the risk of CVD in the general population. Monitoring long-term changes in TyG may assist with in the early identification of individuals at high risk of CVD.

Main results