国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Change in triglyceride-glucose index predicts the risk of cardiovascular disease in the general population: a prospective cohort study

第一作者：Anxin Wang,Xue Tian

通讯作者：Shouling Wu,Yongjun Wang

Triglyceride-glucose index; Longitudinal changes; Cardiovascular disease; Stroke; Myocardial infarction; Predictive value

基本信息

2021-05-26

已发表文章

发表杂志：Cardiovascular Diabetology

发表类型: Original Contributions

影响因子(IF): 9.951

PMID: https://pubmed.ncbi.nlm.nih.gov/34039351/ Pubmed原文链接 全文下载

主要研究背景及目的

Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and subsequent cardiovascular disease (CVD). However, the effect of longitudinal changes in TyG index on the risk of CVD remains uncertain. This study aimed to investigate the association between change in TyG index and the risk of CVD in the general population.

方法

The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2], and change in TyG index was defined as the difference between the TyG index in 2010 and that in 2006. Multivariable-adjusted Cox proportional hazard models and restricted cubic spline analysis were used to examine the association between change in TyG index and the risk of CVD.

结论

Substantial changes in TyG index independently predict the risk of CVD in the general population. Monitoring long-term changes in TyG may assist with in the early identification of individuals at high risk of CVD.

主要结果