Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Differential Associations of Lipoprotein(a) Level with Cerebral Large Artery and Small Vessel Diseases: The PRECISE study
First author：Yuesong Pan, Xueli Cai
Corresponding author：Yongjun Wang, Yilong Wang
essential_information
- Person in charge：Yuesong Pan, Xueli Cai
- Data Sources： PRECISE
- Number of papers：PRECISE20210211
- Published time：2022-07-18
2022-07-18
Published articles
Journal：Stroke and Vascular Neurology
Publication type: Original Contributions
IF(IF): 9.893
PMID: 35851316 Link To Pubmed Full text Download
Background And Purpose
Cerebral large artery and small vessel diseases are related to different pathogenetic mechanisms and have different risk factor profile. This study aimed to examine the associations of Lipoprotein(a) [Lp(a)] level with the two types of cerebrovascular diseases.
Method
logistic regression
Conclusion
In this study, Lp(a) concentrations were positively associated with presence and burden of intracranial atherosclerosis, but was inversely associated with cSVD.
Main results
This study included 3059 subjects. The average age of the participants was 61.2±6.7 years, and 53.5% (1636) were female. Compared with the first tertile, subjects with the second and third tertiles of Lp(a) concentrations were associated with an increased odds of presence of intracranial plaque (18.7% vs 15.4%, adj.OR 1.37, 95% CI 1.08 to 1.75; 18.9% vs 15.4%, adj.OR 1.34, 95% CI 1.05 to 1.72). Similar associations were observed for intracranial atherosclerotic burden. Whereas, subjects with the third tertile of Lp(a) level had a decreased odds of presence of cSVD (25.9% vs 31.7%, adj.OR 0.74, 95% CI 0.60 to 0.92) and lower cSVD burden (adj.cOR 0.76, 95% CI 0.62 to 0.94).