国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Differential Associations of Lipoprotein(a) Level with Cerebral Large Artery and Small Vessel Diseases: The PRECISE study

第一作者：Yuesong Pan, Xueli Cai

通讯作者：Yongjun Wang, Yilong Wang

Lp(a) ischaemic stroke cerebral small vessel diseases

基本信息

2022-07-18

已发表文章

发表杂志：Stroke and Vascular Neurology

发表类型: Original Contributions

影响因子(IF): 9.893

PMID: 35851316 Pubmed原文链接 全文下载

主要研究背景及目的

Cerebral large artery and small vessel diseases are related to different pathogenetic mechanisms and have different risk factor profile. This study aimed to examine the associations of Lipoprotein(a) [Lp(a)] level with the two types of cerebrovascular diseases.

方法

logistic regression

结论

In this study, Lp(a) concentrations were positively associated with presence and burden of intracranial atherosclerosis, but was inversely associated with cSVD.

主要结果

This study included 3059 subjects. The average age of the participants was 61.2±6.7 years, and 53.5% (1636) were female. Compared with the first tertile, subjects with the second and third tertiles of Lp(a) concentrations were associated with an increased odds of presence of intracranial plaque (18.7% vs 15.4%, adj.OR 1.37, 95% CI 1.08 to 1.75; 18.9% vs 15.4%, adj.OR 1.34, 95% CI 1.05 to 1.72). Similar associations were observed for intracranial atherosclerotic burden. Whereas, subjects with the third tertile of Lp(a) level had a decreased odds of presence of cSVD (25.9% vs 31.7%, adj.OR 0.74, 95% CI 0.60 to 0.92) and lower cSVD burden (adj.cOR 0.76, 95% CI 0.62 to 0.94).