Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of Insulin Resistance with Intra- and Extra-cranial Atherosclerotic Burden in the Nondiabetic Community Population
First author：Xueli Cai,Jingping Sun
Corresponding author：Yuesong Pan
essential_information
- Person in charge：Xueli Cai,Jingping Sun
- Data Sources： PRECISE
- Number of papers：PRECISE20220006
- Published time：2023-08-23
2023-08-23
Published articles
Journal：Neurobiology of Disease
Publication type: Cohort Study
IF(IF): 6.1
PMID: 37625526 Link To Pubmed Full text Download
Background And Purpose
Few population-based studies have investigated the association between insulin resistance and atherosclerotic burden in intra- and extra-cranial arteries. The purpose of this study is to explore the relationship between insulin resistance and intra- and extra-cranial atherosclerotic burden in community-based nondiabetic participants.
Method
We will use binary or ordinal logistic regression to assess the association between HOMA-IR or ISI0-120 and the presence and burden of atherosclerosis.
Conclusion
Insulin resistance was associated with an increased intra-and extra-cranial atherosclerotic burden in the nondiabetic elderly Chinese population.
Main results
Among the 2754 participants, the mean age was 60.9±6.6 years, and 1,296 (47.1%) were males. Compared with the lowest quartile of HOMR-IR, the highest quartile of HOMA-IR (indicating a higher level of insulin resistance) was associated with an increased presence of plaques (OR:1.54, 95% CI:1.14-2.08), and atherosclerotic burden (OR:1.53, 95%CI:1.14-2.07) in intracranial arteries. Meanwhile, we observed a similar relationship between HOMA-IR and the presence or burden in extracranial atherosclerosis. The first (indicating a higher level of insulin resistance) quartiles of ISI0-120 were associated with the intracranial plaques (Q1, OR:1.56, 95%CI:1.16-2.11) and atherosclerotic burden (Q1, OR:1.57, 95%CI:1.17-2.12), but not extracranial plaques or atherosclerotic burden, compared with the fourth quartile of ISI0-120.