国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of Insulin Resistance with Intra- and Extra-cranial Atherosclerotic Burden in the Nondiabetic Community Population

第一作者：Xueli Cai,Jingping Sun

通讯作者：Yuesong Pan

Insulin resistance Atherosclerotic burden

基本信息

2023-08-23

已发表文章

发表杂志：Neurobiology of Disease

发表类型: Cohort Study

影响因子(IF): 6.1

PMID: 37625526 Pubmed原文链接 全文下载

主要研究背景及目的

Few population-based studies have investigated the association between insulin resistance and atherosclerotic burden in intra- and extra-cranial arteries. The purpose of this study is to explore the relationship between insulin resistance and intra- and extra-cranial atherosclerotic burden in community-based nondiabetic participants.

方法

We will use binary or ordinal logistic regression to assess the association between HOMA-IR or ISI0-120 and the presence and burden of atherosclerosis.

结论

Insulin resistance was associated with an increased intra-and extra-cranial atherosclerotic burden in the nondiabetic elderly Chinese population.

主要结果

Among the 2754 participants, the mean age was 60.9±6.6 years, and 1,296 (47.1%) were males. Compared with the lowest quartile of HOMR-IR, the highest quartile of HOMA-IR (indicating a higher level of insulin resistance) was associated with an increased presence of plaques (OR:1.54, 95% CI:1.14-2.08), and atherosclerotic burden (OR:1.53, 95%CI:1.14-2.07) in intracranial arteries. Meanwhile, we observed a similar relationship between HOMA-IR and the presence or burden in extracranial atherosclerosis. The first (indicating a higher level of insulin resistance) quartiles of ISI0-120 were associated with the intracranial plaques (Q1, OR:1.56, 95%CI:1.16-2.11) and atherosclerotic burden (Q1, OR:1.57, 95%CI:1.17-2.12), but not extracranial plaques or atherosclerotic burden, compared with the fourth quartile of ISI0-120.