Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Higher visceral adiposity index and lipid accumulation product in relation to increased risk of atherosclerotic burden in community-dwelling older adults
First author：Jingping Sun,Xia Meng
Corresponding author：Tiemin Wei,Xueli Cai
essential_information
- Person in charge：Jingping Sun,Xia Meng
- Data Sources： PRECISE
- Number of papers：PRECISE20220037
- Published time：2023-02-02
2023-02-02
Published articles
Journal：Experimental Gerontology
Publication type: Cohort Study
IF(IF): 4.25
PMID: 36758647 Link To Pubmed Full text Download
Background And Purpose
Emerging studies showed that the visceral adiposity index (VAI) and lipid accumulation product (LAP) assessed the visceral adipose dysfunction and central lipid accumulation, which was strongly associated with cardiovascular disease. However, few studies investigated the association between two indexes (VAI and LAP) and atherosclerotic burden for the major coronary, intracranial, and extracranial arteries in community-dwelling older adults. We aimed to evaluate the association between VAI or LAP and atherosclerotic burden in an asymptomatic Chinese elderly population.
Method
Participants without a history of CVD in the study of PRECISE (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) were included. The sex-special indicators of VAI and LAP were calculated and stratified by the tertiles. The presence of plaque and coronary segmental stenosis score (SSS) were assessed by coronary computed tomography (CTA), as well as intracranial and extracranial atherosclerotic burden were evaluated by high-resolution magnetic resonance imaging (HR-MRI), respectively. Binary or ordinal logistic regression was conducted to assess the association between each of the indexes and the presence and burden of atherosclerosis.
Conclusion
Among community-dwelling asymptomatic older adults, VAI and LAP were associated with the presence and burden of coronary atherosclerotic plaques, while VAI presented a weaker significant association with extracranial atherosclerosis in females.
Main results
A total of 2875 subjects were included in the final analysis. The mean age was 60.9 ± 6.6 years and 1329 (46.2 %) participants were males. Compared with the first tertile of VAI, the higher tertile was associated with the presence of plaques (T3 vs T1, OR, 1.49, 95%CI, 1.12–1.98, for males; OR, 1.64, 95%CI, 1.24–2.17, for females) and atherosclerotic burden (T3 vs T1, adjusted cOR, 1.63, 95%CI, 1.24–2.14, for males; adjusted cOR,1.70, 95%CI, 1.29–2.24, for females) in major coronary arteries. A similar association was found for LAP. VAI level has presented an association with the extracranial atherosclerotic plaques (T3 vs T1, OR, 1.34, 95%CI,1.02–1.77) and burden (T3 vs T1, adjusted cOR 1.32, 95 % CI 1.00–1.73) only in females. Whereas, for intracranial atherosclerosis, the results failed to show any statistically significant association.