国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Higher visceral adiposity index and lipid accumulation product in relation to increased risk of atherosclerotic burden in community-dwelling older adults

第一作者：Jingping Sun,Xia Meng

通讯作者：Tiemin Wei,Xueli Cai

Visceral adiposity index Lipid accumulation product Coronary atherosclerosis Intracranial and extracranial atherosclerosis

基本信息

2023-02-02

已发表文章

发表杂志：Experimental Gerontology

发表类型: Cohort Study

影响因子(IF): 4.25

PMID: 36758647 Pubmed原文链接 全文下载

主要研究背景及目的

Emerging studies showed that the visceral adiposity index (VAI) and lipid accumulation product (LAP) assessed the visceral adipose dysfunction and central lipid accumulation, which was strongly associated with cardiovascular disease. However, few studies investigated the association between two indexes (VAI and LAP) and atherosclerotic burden for the major coronary, intracranial, and extracranial arteries in community-dwelling older adults. We aimed to evaluate the association between VAI or LAP and atherosclerotic burden in an asymptomatic Chinese elderly population.

方法

Participants without a history of CVD in the study of PRECISE (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) were included. The sex-special indicators of VAI and LAP were calculated and stratified by the tertiles. The presence of plaque and coronary segmental stenosis score (SSS) were assessed by coronary computed tomography (CTA), as well as intracranial and extracranial atherosclerotic burden were evaluated by high-resolution magnetic resonance imaging (HR-MRI), respectively. Binary or ordinal logistic regression was conducted to assess the association between each of the indexes and the presence and burden of atherosclerosis.

结论

Among community-dwelling asymptomatic older adults, VAI and LAP were associated with the presence and burden of coronary atherosclerotic plaques, while VAI presented a weaker significant association with extracranial atherosclerosis in females.

主要结果

A total of 2875 subjects were included in the final analysis. The mean age was 60.9 ± 6.6 years and 1329 (46.2 %) participants were males. Compared with the first tertile of VAI, the higher tertile was associated with the presence of plaques (T3 vs T1, OR, 1.49, 95%CI, 1.12–1.98, for males; OR, 1.64, 95%CI, 1.24–2.17, for females) and atherosclerotic burden (T3 vs T1, adjusted cOR, 1.63, 95%CI, 1.24–2.14, for males; adjusted cOR,1.70, 95%CI, 1.29–2.24, for females) in major coronary arteries. A similar association was found for LAP. VAI level has presented an association with the extracranial atherosclerotic plaques (T3 vs T1, OR, 1.34, 95%CI,1.02–1.77) and burden (T3 vs T1, adjusted cOR 1.32, 95 % CI 1.00–1.73) only in females. Whereas, for intracranial atherosclerosis, the results failed to show any statistically significant association.