Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Revisiting the smoking paradox in acute ischemic stroke patients: findings from the Chinese Stroke Center Alliance Study
First author：Guoliang Hu
Corresponding author：Yilong Wang
essential_information
- Person in charge：Guoliang Hu
- Data Sources： CSCA
- Number of papers：CSCA20220063
- Published time：2023-08-07
2023-08-07
Published articles
Journal：Journal of the American Heart Association
Publication type: Original Article
IF(IF): 5.4
PMID: 37548171 Link To Pubmed Full text Download
Background And Purpose
The observation that smokers with acute ischemic stroke could have better outcomes than nonsmokers led to the term “smoking paradox.” The controversy of such a complex claim has not been fully settled. Analyses were conducted on a nationwide data set to evaluate and determine whether such a paradox truly exists.
Method
Continuous variables were described as mean (standard deviation [SD]) for normally distributed data and median (interquartile range [IQR]) for skewed data. Categorical variables were presented as the number (percentage). Logistic multivariable regression analysis was carried out to examine the association between smoking and in-hospital outcomes. Subgroup analysis was performed. In addition, we conducted a propensity-score matched analysis to further confirm the association between smoking and in-hospital outcomes.
Conclusion
Smoking was associated with increased risk of adverse in-hospital outcomes among patients with AIS in contemporary practice, reinforcing the importance of smoking cessation in patients with AIS.