国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Revisiting the smoking paradox in acute ischemic stroke patients: findings from the Chinese Stroke Center Alliance Study

第一作者：Guoliang Hu

通讯作者：Yilong Wang

acute ischemic stroke in-hospital outcomes smoke smoking paradox

基本信息

  • 负责人：Guoliang Hu
  • 数据来源： CSCA
  • 论文编号：CSCA20220063
  • 发表时间：2023-08-07

2023-08-07

已发表文章

发表杂志：Journal of the American Heart Association

发表类型: Original Article

影响因子(IF): 5.4

PMID: 37548171 Pubmed原文链接 全文下载

主要研究背景及目的

The observation that smokers with acute ischemic stroke could have better outcomes than nonsmokers led to the term “smoking paradox.” The controversy of such a complex claim has not been fully settled. Analyses were conducted on a nationwide data set to evaluate and determine whether such a paradox truly exists.

方法

Continuous variables were described as mean (standard deviation [SD]) for normally distributed data and median (interquartile range [IQR]) for skewed data. Categorical variables were presented as the number (percentage). Logistic multivariable regression analysis was carried out to examine the association between smoking and in-hospital outcomes. Subgroup analysis was performed. In addition, we conducted a propensity-score matched analysis to further confirm the association between smoking and in-hospital outcomes.

结论

Smoking was associated with increased risk of adverse in-hospital outcomes among patients with AIS in contemporary practice, reinforcing the importance of smoking cessation in patients with AIS.

主要结果