Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Discordance of Apolipoprotein B with Low-Density Lipoprotein Cholesterol or Non-High Density Lipoprotein cholesterol and Coronary Atherosclerosis
First author：Xin Su,Xueli Cai
Corresponding author：Yan He,Tieming Wei
essential_information
- Person in charge：Xin Su,Xueli Cai
- Data Sources： PRECISE
- Number of papers：PRECISE20220098
- Published time：2022-09-27
2022-09-27
Published articles
Journal：European Journal of Preventive Cardiology
Publication type: Original Research Article
IF(IF): 8.526
PMID: 36166398 Link To Pubmed Full text Download
Background And Purpose
High level of apolipoprotein B (Apo B) is associated with incident coronary artery disease (CAD) when low-density lipoprotein cholesterol (LDL-C) level or non–high density lipoprotein cholesterol (non–HDL-C) is low. However, data on the relationship of Apo B with coronary atherosclerosis plaques burden are limited. The present study aimed to estimate associations between Apo B with the presence and burden of coronary atherosclerosis plaques.
Method
Multivariate binary logistic regression and multivariate ordinal logistic regression. Discordance analysis defining based on residuals and medians.
Conclusion
Discordantly high Apo B with LDL-C and non-HDL-C were associated with an increased odds of the coronary atherosclerotic plaques and its burden. These findings highlighted the importance of Apo B for primary prevention of coronary atherosclerosis.